General Information
Genome-wide association studies (GWAS) map genetic variants associated with diseases across the genome. Infinium HD BeadChips offer GWAS researchers the flexibility to profile samples in various multiplex formats, and deliver dense genome-wide coverage with carefully selected tag SNPs.
Illumina’s unique BeadArray technology is based on 3 micron silica beads that self assemble in microwells on planar silica slides. Each bead is covered with hundreds of thousands of copies of a specific oligonucleotide, which act as the capture sequence in the Infinium HD Assay protocol. Outstanding characteristics of the BeadArray technology include 100% quality control of every single array, and high feature-redundancy (>20x average) providing high-confidence results.
Illumina’s Whole-Genome Human SNP Genotyping Portfolio
| Infinium HD Bead Chips |
samples/chip |
markers per sample |
| Human1M-Duo |
2 |
>1 million |
| HumanOmni1-Quad |
4 |
>1 million, incl. content from the ”1000 Genomes Project” |
| HumanOmniExpress |
12 |
>700,000 |
| Human660W-Quad |
4 |
>658,000 |
In 2010, Illumina plans to add new SNPs from the ”1000 Genomes Project” to its HD bead chips, which shall result in a 5M chip covering many SNPs with minor allele frequencies as low as 1%.
Service range
Our Full Service covers the complete process, from quality control of genomic DNA, to determination of genotypes.
Quality control
ATLAS Biolabs is certified according to the international norm DIN EN ISO 9001:2008. Our production processes are subject to rigorous quality control at all steps:
- Quality and quantity control of genomic DNA by agarose gel analysis
- Negative control in each sample processing batch to exclude DNA contamination
- Positive control in each sample processing batch to ensure a technically correct laboratory process
- All quality assurance procedures are electronically documented and available for our customers on demand
