molecular genetic analyses

Bioinformatics Service

General Information

The handling of data from high-throughput sequencing projects or microarray experiments requires a thorough expertise in statistics, bioinformatics and information technology. ATLAS Biolabs can offer you this expertise in a standardised manner for expression profiling experiments as well as Single Nucleotide Polymorphism (SNP) genotyping. This insures that our customers receive fast and reliable results upon completion of microarray analyses.

Why Choose ATLAS Biolabs’ Services?

  • ATLAS Biolabs is an Authorised Affymetrix Service Provider
  • ATLAS Biolabs is certified according to the international norm DIN EN ISO 9001:2008
  • ATLAS Biolabs’ personnel have successfully analysed tens of thousands of microarrays since 2001
  • Our service is fast (processing of up to 100 samples per day) and extremely reliable
  • We offer professional assistance for both planning experiments as well as further data analysis and interpretation

Bioinformatics Service Portfolio

Expression Data Analysis

Comprehensive analysis of Affymetrix or Agilent expression data
CNV / LOH Data Analysis

Sophisticated analysis of Affymetrix or Illumina SNP data
Bioinformatics Support

Additional service: data analysis, data mining, development
Standardised analysis reports based on over 10 years of experience

Easily interpret data across multiple gene expression experiments

Evaluate quality of experiment through statistical methods

Comprehensive data annotation for the most top significant genes (Unigene, Entrez Gene, Uniprot, GeneOntology, etc.)

Graphical data representations (heat map, principal component analysis, hierarchical clustering)
Easily identify aberrations with affected genes and SNPs

Graphical representation of aberrations across chromosome
Statistics, bioinformatics or IT support for customer specific project needs

Custom analyses (sequencing, expression, exon or genotyping data)

Project definition (consulting, specification, setup)

Software engineering, testing and validation

Data hosting in managed data centre

Service Range

Furthermore, these processes can be optimised to meet your individual project needs. Our bioinformatics service is continuously extended and validated. Analysed data can comprehensively be annotated with information from various data sources, e. g. NCBI Unigene, Entrez Gene, UniProt, Ensembl, OMIM, KEGG Pathways etc. Data can be provided in different formats as MS Excel spreadsheet or as comma or tabulator separated value lists.

  • Expression Data Analysis: Based on customer expression data a report of standard statistical methods (M versus A analysis, Principal Component analysis, Clustering, t-test, ANOVA, False Discovery Rate) as well as most statistically significant genes (Annotation, Metabolic Pathways, GeneOntologies) is generated.
  • CNV / LOH Data Analysis: Based on customer SNP array data, a report with detected chromosomal aberrations is generated. The aberrations are annotated with affected genes and SNPs. The report includes a genome-wide chromosome view indicating aberrations.

Data Delivery

  • Timeline: 3–4 weeks after receipt of samples (for >50 samples, please inquire)
  • CD-ROM/DVD/external HDD sent to customer includes all original data (raw data), as well as the genotype data in XLS or TXT format
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Heatmap of top regulated genes

Chromosome

 

Top 100 Annotations

 

Iso 9001
ISO 9001 service at ATLAS Biolabs is always oriented along internal quality rules which guarantee a constant quality of our work.

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